Pfizer rheumatoid arthritis drug passes clinical hurdle
A rheumatoid arthritis medicine discovered and developed by Pfizer Inc. scientists in Groton and New London showed promise in reducing the physical symptoms of the disease, including swelling and sore joints, according to a clinical study released today.
The study of the experimental drug tofacitinib, a so-called JAK inhibitor previously known as tasocitinib, was the second successful late-stage trial of the Pfizer pill, which would be a major breakthrough for rheumatoid arthritis sufferers. A previous study showed the drug reduced pain and inflammation for nearly three-quarters of disease sufferers.
“No new safety signal was detected,” Pfizer noted in a summary of the study findings.
Rheumatoid arthritis, an autoimmune disease that causes inflammation in the joints, affects an estimated 1.3 million people in the United States, the company said. The overall market for disease sufferers worldwide has been estimated at $13 billion, with tofacitinib expected to bring in up to $2 billion annually if it eventually wins regulatory approval, most likely next year.
Pfizer is currently finishing four other clinical trials for tofacitinib. The results are expected by the middle of this year.
Article source: http://www.theday.com/article/20110304/BIZ02/110309845/1047/frontpageMobile
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What is Arthritis?
Arthritis is a term that groups over 100 different medical conditions under one umbrella. Often, when a person says arthritis, they speak of it as a single disease, but its various conditions affect over 300,000 children and 46 million adults in the United States. Osteoarthritis is the most common form which affects individuals over the age of 60, however, individuals can have some type of joint deterioration as early as infants. This condition can affect individuals who are just beginning in their lives as young adults, as well as individuals who are at their peak child-rearing and career years.
When damage occurs to the tissue between the joints that allows the bones to slide against one another, inflammation, damage to that joint cartilage, pain and chronic stiffness occurs – arthritis. This disease affects the musculosketal system within the joints, and covers over 100 different kinds of conditions that have the root in this affected place. If left untreated and not caught early enough, deformities occur as well as weakness, and brittleness of the bones, which depends upon where the issue begins. Every day activities are strongly affected, and individuals can find it difficult to do small tasks such as tying their shoe laces, walking, or cutting food.
Most people think that arthritis is restricted only to joints, but unfortunately this disease also affects nearly any organ in the human body or in the system of the human body. Some other affected areas are blood vessels, heart, skin, kidneys and lungs. Conditions relating to this disease typically affect the bones and muscles primarily, but they do affect organs as well. Disability in the United States is largely related to both the related conditions and the disease itself which constitutes $124 billion of medical costs for care as well as the lost wages and other indirect expenses that are a result of the onslaught of arthritis.
The loss of production as a result of the amount of arthritis sufferers is also included in the $124 billion per year loss, and the cost continues to rise. The deterioration of health, independence and even physical abilities continues to cost millions of people the valuable quality of life that they have worked hard to maintain. Change is necessary and important in the ability to make this issue better, but as the age of individuals becomes older the risks rise. It is possible to find the much needed cures and advanced treatments needed to stop this debilitating disease altogether with the help of continued research.
Arthritis Treatment |Types and Treatment for Arthritis
Arthritis is the swelling of the joints. This is a rather common disease that can affect any age group. There are over 100 types of arthritis with differing causes, symptoms and treatments. Let’s take a closer look at the common types, symptoms and treatment of arthritis.
Of the different types of arthritis osteoarthritis, rheumatoid and gout are the most common. Osteoarthritis is caused by the wearing of the cartilage layer between bones and is most difficult to treat.
Gout is due to accumulation and formulation of monosodium urate crystals or MSU crystals. This causes inflammation and pain in the joints, typically the big toes. The damage caused by gout is not limited to the joints but can spread to the other body parts such as kidney as well.
Rheumatoid is due to disorder of body’s immune system. All the joints in the body are susceptible to rheumatoid. There is no permanent arthritis treatment in general.
The surgical treatment for arthritis may involve removal of damaged cartilage tissues, shaping or reshaping of bones that may involve bone grafting or use of artificial material as well. In extreme cases entire joint can be removed as well.
Overall although it’s not a simple disease, there are various remedies and treatment for arthritis that can help an arthritis patient live a full and happy life.
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